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D-biotin Feed Grade
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Properties
Product Name D-Biotin Feed Grade
CAS Number 58-85-5
Formula C10H16N2O3S
Molar Mass 244.31 g/mol
Pub Chem CID 171548
Drug Bank DB00121
Chem Spider 14916
Bioavailability 50%
Protein Binding 80%
Metabolism Liver
Elimination Halflife 26 Hours
FAQ
What is D-Biotin Feed Grade, and how is it used in animal nutrition?

D-Biotin Feed Grade, often referred to simply as Biotin, is a water-soluble B-vitamin (Vitamin B7) essential for various metabolic processes in animals. It plays a crucial role in the metabolism of carbohydrates, fats, and proteins, making it vital for optimal animal growth, reproduction, and overall health. In livestock and poultry, Biotin deficiencies can lead to issues such as poor hoof and claw health, dermatitis, alopecia, and stunted growth. Therefore, D-Biotin is typically added to animal feed to ensure these deficiencies do not occur.

Its application varies across different species and production stages. For instance, in swine, supplementing with Biotin can improve hoof health and enhance reproductive performance. In poultry, it contributes to feathering, skin health, and egg quality. Dairy cows benefit from Biotin through improved hoof integrity and milk production. The recommended dosages are species-specific and should be adhered to based on veterinary guidance or established nutritional standards.

How does D-Biotin benefit the health and productivity of livestock and poultry?

The inclusion of D-Biotin in animal feed is associated with several significant health and productivity benefits. One of the primary benefits is its role in maintaining the integrity of skin, hooves, and feathers. In livestock such as swine and cattle, Biotin supplementation has been shown to prevent or alleviate hoof-related issues such as cracks and lesions, which can improve mobility and decrease the incidence of lameness. Healthy hooves directly translate to more productive and comfortable animals.

For poultry, Biotin is critical for proper feathering, skin health, and overall vitality. Deficiencies can result in poor feather condition, scaly dermatitis, and reduced egg production and quality. Adequate levels help in maintaining egg shell strength and texture, crucial for reaching optimal production efficiency. Additionally, for breeding animals, Biotin supports reproductive health, enhancing fertility rates and ensuring the birth of healthy offspring.

What are the signs of Biotin deficiency in animals, and how can it be identified?

Biotin deficiency in animals can manifest in several ways, depending on the species. Common signs across different animals include dermatitis, hair or feather loss, and poor overall growth. Specifically, in poultry, symptoms of deficiency include footpad dermatitis, cracked feet, poor feathering, and decreased egg production and hatchability. For swine, signs can encompass skin lesions, cracked hooves, poor coat condition, and reproductive issues such as reduced litter sizes or weak piglets.

In ruminants, visible symptoms might include lameness due to soft or cracked hooves, alopecia, and reduced milk yield in dairy cows. Diagnosing Biotin deficiency usually involves a combination of observing these clinical symptoms and assessing dietary history. Veterinarians and animal nutritionists often conduct feed analyses to determine if Biotin levels fall below the recommended thresholds. Maintaining regular health and feed assessments can help prevent Biotin deficiency before clinical symptoms become severe.

What factors can lead to Biotin deficiency in animal diets?

Several factors can contribute to Biotin deficiency in animal diets. One of the primary reasons is inadequate dietary provision. Since Biotin is a water-soluble vitamin, it cannot be stored in the body for long periods, necessitating a consistent and adequate dietary supply. Feed formulation errors or reliance on feed ingredients with inherently low Biotin levels can precipitate a deficiency.

Antagonists present in the diet can also interfere with Biotin absorption. For instance, raw egg whites contain avidin, a protein that binds to Biotin and prevents its absorption in the gut. Additionally, some common feed ingredients, such as grains and oilseed meals, can contain antinutritional factors that inhibit Biotin's bioavailability. Finally, stress factors like rapid growth phases, high production levels, and environmental stressors can increase Biotin requirements, making previously adequate levels insufficient under these new conditions.

How should D-Biotin Feed Grade be incorporated into animal feed formulations?

Incorporating D-Biotin Feed Grade into animal feed formulations involves several steps to ensure effectiveness and stability. Initially, it's crucial to determine the species-specific requirements, which can vary significantly. For example, the Biotin requirements for poultry, swine, and ruminants differ based on their metabolic needs and production stages. Therefore, conducting a nutritional assessment or consulting a veterinarian or animal nutritionist is essential for accurate formulation.

Once the required dosages are established, D-Biotin can be mixed into the feed uniformly to ensure all animals receive the intended supplementation. Depending on the feed production process, D-Biotin can be added directly to premixes or to the final feed during the mixing phase. It’s imperative to consider the stability of Biotin during feed processing, such as pelleting, as excessive heat can degrade the vitamin. Ensuring proper storage conditions for both the Biotin supplement and the final feed is also vital. Keeping products in a cool, dry place helps maintain Biotin’s stability and efficacy.

Are there any interactions or contraindications to be aware of when using D-Biotin Feed Grade?

While D-Biotin is generally safe and well-tolerated in animal diets, certain interactions and contraindications should be considered. One notable interaction occurs with the protein avidin found in raw egg whites, which can bind to Biotin and inhibit its absorption. Although this is more pertinent to mono-gastric animals such as poultry and swine, it’s an essential factor to consider in feed formulations where raw egg products might be used.

Furthermore, the presence of certain drugs and antibiotics in animal diets can impact Biotin metabolism and absorption. For example, long-term antibiotic use can disrupt gut flora, reducing the synthesis of Biotin by gut bacteria, primarily in ruminants who rely on microbial synthesis for their vitamin needs. It’s also essential to balance Biotin with other B vitamins, as deficiencies or excesses in one can affect the metabolism of the others.

What is the recommended dosage of D-Biotin for different animal species?

The recommended dosage of D-Biotin varies among different animal species and their respective production stages. For poultry, the average recommended dose ranges from 50 to 200 micrograms per kilogram of feed, depending on factors such as age, production scale, and stress levels. Higher doses might be necessary during peak production or breeding phases to optimize feathering and skin health.

In swine, the recommended dosage can range from 150 to 400 micrograms per kilogram of feed. Growing pigs and sows, particularly during reproductive stages, may require higher levels to ensure hoof health and reproductive efficacy. For ruminants such as dairy cows, the dosage recommendations typically range from 20 to 40 milligrams per day, focusing primarily on maintaining hoof integrity and improving milk production. Accurate dosing is crucial and should be tailored to the animal's specific needs and production conditions, often requiring professional guidance from veterinarians or nutritionists.
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